孙慧妍

职称:副教授、博士生导师

毕业院校:吉林大学

email:huiyansun@jlu.edu.cn

个人主页:https://www.researchgate.net/profile/Huiyan_Sun2

研究方向:机器学习、因果推断、生物信息学、精准医学

个人简介

孙慧妍,吉林大学人工智能学院副教授,吉林大学口腔医院双聘教师,博士生导师。从事人工智能及因果推断与生物医学交叉学科研究。近五年,以第一作者或通讯作者发表在《Cancer Research》、《National Science Review》、《Genomics, Proteomics & Bioinformatics》、AAAI等高水平杂志和国际人工智能顶级会议上发表论文10余篇,其他及参与发表论文10余篇。H-index =11。目前主持国家自然科学基金青年项目1项;参与国家自然科学基金重点、面上项目3项。任国际生物医学信息学会议AAAI, IEEE BIBM, CIKM, BIOKDD程序委员会成员,Bioinformatics, IEEE TKDE等杂志审稿人。获ACM SIGBIO CHINA 2022新星奖。


工作经历

2021.05 —— 至今          吉林大学人工智能学院 副教授

2019.05 —— 2021.05    吉林大学人工智能学院 助理教授

2017.06 —— 2017.12    澳门大学健康科学学院 研究助理

2014.06 —— 2016.12    美国佐治亚大学生物化学与分子生物学学院 访问学生

教育经历

2011.09 —— 2018.12    吉林大学计算机科学与技术学院生物信息学专业 硕博连读

2007.09 —— 2011.06    吉林大学计算机科学与技术学院计算机科学与技术专业 本科

科研项目

1. 2020.01-2022.12:国家自然科学基金委:基于单样本边扰动网络的癌症个体化诊疗研究,25万,主持人

2. 2020.01-2023.12:国家自然科学基金委:基于深度学习的个性化基因组与药物相互作用研究,56万,参与人

3. 2020.01-2023.12:国家自然科学基金委:融合群智能的大规模生物医学知识图谱构建及推理理论与方法,237万,参与人

4. 2015.01-2018.12:国家自然科学基金委:全基因组重测序数据高维SNP相互作用研究,80万,参与人

5. 2013.01-2016.12:国家自然科学基金委:基于农作物高通量表达谱数据的特征选择与分子网络构建的评估算法,80万,参与人

论文选

详见个人主页,近五年部分论文信息如下:(以下论文中,+为共同第一作者, *为通讯作者)

17. Yijun Liu, Ji Sun, Huiyan Sun*, Yi Chang*.(2022) Identification of key somatic oncogenic mutation based on a confounder-free causal inference model. PLOS Computational Biology, doi:10.1371/journal.pcbi.1010529  

16. Qiang Huang, Jundong Li, Huiyan Sun*, Yi Chang*. SemiITE: Semi-supervised Individual Treatment Effect Estimation via Disagreement-Based Co-training. ECML-PKDD 2022 (CCF-B会议)

15. Huiyan Sun+, Yi Zhou+, Michael Francis Skaro, Yiran Wu, Zexing Qu, Fenglou Mao, Suwen Zhao, Ying Xu*. (2020). Metabolic Reprogramming in Cancer is Induced to Increase Proton Production. Cancer Research, DOI: 10.1158/0008-5472.CAN-19-3392.  (中科院一区, Nature Index 期刊)

14. Yi Zhou+, Huiyan Sun+, Ying Xu*. (2020). Metabolic reprogramming in cancer: The bridge that connects intracellular stresses and cancer behaviors. National Science Review 7(8):1270-1273. (中科院一区)

13. Liang Chen+, Changliang Wang+, Huiyan Sun+, Juexin Wang, Yanchun Liang, Garry Wong*. (2020). The bioinformatics toolbox for circRNA discovery and analysis. Briefings in Bioinformatics, DOI: 10.1093/bib/bbaa001. (中科院一区)

12. Qiang Huang, Tingyu Xia, Huiyan Sun*, Makoto Yamada*, Yi Chang. Unsupervised Nonlinear Feature Selection from High-dimensional Signed Networks. AAAI 2020. (CCF-A会议)

11. Sun Huiyan, Chen Liang, Cao Sha, Liang Yanchun, Xu Ying*. (2019). Warburg Effects in Cancer and Normal Proliferating Cells: Two Tales of the Same Name. Genomics, Proteomics & Bioinformatics,17(3). (中科院一区)

10. Sun Huiyan , Zhang Chi, Cao Sha, Sheng Tao, Dong Ning, Xu Ying*. (2018). Fenton reactions drive nucleotide and ATP syntheses in cancer, Journal of Molecular Cell Biology,10(5):448-459. (中科院二区)

9. Huiyan Sun+, Yi Zhou+, Hongyang Jiang, Ying Xu*. (2020). Elucidation of Functional Roles of Sialic Acids in Cancer Migration. Frontiers in Oncology, DOI: 10.3389/fonc.2020.00401. (中科院二区)

8. Yingze Xu, Yan Wang*, Xuping Xie, Feilong Wang, Qi Chen, Huiyan Sun* (2021) An AutoEncoder-Based Matrix Factorization Approach to Estimating Cell Proportion from Bulk Tumor RNA-seq Data IEEE BIBM. (CCF-B会议)

7. Hongyang Jiang+, Zhihang Wang+, Chaoyi Yin, Peishuo Sun, Ying Xu*, Huiyan Sun*. (2020). Identification of Cancer Development Related Pathways Based on Co-Expression Analyses. IEEE BIBM 2020. (CCF-B会议)

6. Jiang Hongyang, Huang Qiang, Chen Liang, Li Zhi, Xu Ying, Sun Huiyan*, Chang Yi, Multi-classification of Cancer Samples based on Co-expression Analyses. IEEE BIBM 2019. (CCF-B会议)

5. Chaoyi Yin+, Yangkun Cao+, Peishuo Sun, Hengyuan Zhang, Zhi Li*, Ying Xu, Huiyan Sun* (2022) Molecular Subtyping of Cancer based on Robust Graph Neural Network and Multi-omics Data Integration. Frontiers in genetics, doi: 10.3389/fgene.2022.884028 (中科院三区)

4. Peishuo Sun, Ying Wu, Chaoyi Yin, Hongyang Jiang, Ying Xu, Huiyan Sun*. (2022) Molecular Subtyping of Cancer based on Distinguishing Co-expression Modules and Machine Learning. Frontiers in Genetics, doi: 10.3389/fgene.2022.866005(中科院三区)

3. Chen Liang, Sun Huiyan, Wang Changliang, Yang Yang, Zhang Menglei, Wong Garry*.(2018).miRNA Arm Switching Identifies Novel Tumour Biomarkers, Ebiomedicine, 38:37-46. (中科院一区)

2. Wang Xiaoyan, Jiang Bin,  Sun Huiyan, Zheng Dejin, Zhang Zhenwu, Yan Li, Li Enqin, Xu Renhe*. (2018) CXCL12-dependent acetylation of wound healing by topical application of MSC spheres, but not single cells, derived from safety-enhanced Hesc. Theranostics 9(21):6112-6128. doi:10.7150/thno.32982. (中科院一区)

1. Chen Liang, Heikkinen Liisa, Wang Changliang, Yang Yang, Sun Huiyan, Wong Garry*. (2018). Trends in the development of miRNA bioinformatics tools, Briefings in Bioinformatics,20(5). (中科院一区, 高被引论文)

获奖情况

2020年全国商业科技进步奖二等奖

2022 ACM SIGBIO CHINA 新星奖

社会兼职

AAAI、IEEE BIBM、ECML-PKDD、CIKM、BIOKDD 等 PC Member;

IEEE TKDE、Genomics, Proteomics & Bioinformatics (GPB)、Bioinformatics、IEEE/ACM TCBB、BMC Cancer等杂志审稿人;

吉林省人工智能学会理事

计算机学会生物信息学专委会通讯委员

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